Lika Nüssli was born in Flawil in 1973 and grew up in the town of Gossau, in the eastern Swiss canton of St. Gallen. She studied textile design and then illustration at the Lucerne School of Art and Design. Since 2003, she has worked as a freelance artist in the fields of drawing and painting, performance, and installation.

Since 2017, she has invited people to draw with her at the Kunstmuseum St. Gallen. She teaches introductory illustration and drawing courses at the Schule für Gestaltung St. Gallen. She is co-editor of the comics magazine STRAPAZIN and is a member of Visarte Switzerland, PANCH (Performance Art Network CH), ProLitteris, Archiv Ostschweizer Kunstschaffen, Réseau BD (Comic Network Switzerland), SCAA (Swiss Comics Artists Association), Autillus (creators of children's and adolescent books Switzerland), and GdSL (Society for German Language and Literature).

She illustrated several children's books before presenting her first graphic novel, Vergiss dich nicht, for Vexer Verlag in 2018. Her second graphic novel, Starkes Ding, was published by Edition Moderne in 2022 and the publication in Italy is scheduled in 2025 by Sigaretten.

Nüssli has received several awards for her work, including the Comicstipendium der Deutschschweizer Städte in 2016, the Comic-Werkbeitrag of Pro Helvetia in 2021, and the Swiss Literature Prize in 2023 for Starkes Ding.

Lika Nüssli is also co-editor of the comics magazine "Strapazin."